Xov xwm

Hauv cov neeg mob uas mob me me dilated cardiomyopathy (MDCM), nce siab ntawm C-reactive protein ntau (hs-CRP) yog txuam nrog nce qib ntawm N-terminal hlwb natriuretic peptide (NT-proBNP) hauv cov neeg mob me me dilated cardiomyopathy (MDCM) .), txawm hais tias tsis muaj pov thawj los txhawb qhov kev kwv yees cuam tshuam nrog cov txiaj ntsig ntawm tus neeg mob.Cov txiaj ntsig tau luam tawm hauv phau ntawv xov xwm ESC Heart Failure.
Kev tshuaj xyuas rov qab ntawm cov neeg mob uas muaj mob plawv plawv (DCM) thiab sab laug ventricular ejection feem tsawg dua 50% tau mus rau Fuwai Tsev Kho Mob hauv Beijing, Tuam Tshoj txij lub Kaum Ob Hlis 2006 txog Lub Kaum Hli 2017 tau ua.Cov kws tshawb nrhiav nrhiav los sib piv cov biomarkers NT-proBNP thiab hs-CRP hauv MDCM cov neeg mob thiab DCM cov neeg mob.Nyob rau hauv txoj kev tshawb no, MDCM tau txhais tias yog sab laug ventricular end-diastolic txoj kab uas hla index (LVEDDi) ntawm 33 mm / m2 los yog tsawg dua rau cov txiv neej thiab 34 mm / m2 rau cov poj niam.
Tag nrho ntawm 640 tus neeg tuaj koom tau suav nrog hauv kev tshuaj ntsuam, ntawm 17% tau muab cais ua MDCM thiab 83% raug cais raws li muaj DCM ntawm lub hauv paus.Zuag qhia tag nrho, 24.8% ntawm cov neeg koom yog poj niam.Lub hnub nyoog nruab nrab ntawm cov neeg mob yog 49 xyoo.
Piv nrog rau cov neeg koom nrog DCM, MDCM cov neeg mob tseem yau, muaj ntshav siab dua, muaj ntshav qab zib ntau dua, qis qis ntawm cov ventricular tachycardia, lub cev hnyav dua, thiab nyob hauv tsev kho mob luv dua. Hais txog lub plawv biomarkers, cov neeg mob nrog MDCM tau txo qis nruab nrab ntawm NT-proBNP qib piv nrog cov neeg mob DCM (2203 pg / mL vs 1448 pg / mL, feem; P <.001). Hais txog biomarkers, cov neeg mob nrog MDCM tau txo qis nruab nrab ntawm NT-proBNP qib piv nrog cov neeg mob plawv DCM (2203 pg / mL vs 1448 pg / mL, feem; P <.001). Что касается сердечных биомаркеров, у пациентов с MDCM средний уровень NT-proBNP был значительно ниже по сравнению с пациентами с DCM (2203 пг/мл против 1448 пг/мл соответственно; P < 0,001). Hais txog kev mob plawv biomarkers, MDCM cov neeg mob tau qis dua qhov txhais tau tias NT-proBNP qib piv rau cov neeg mob DCM (2203 pg/mL vs. 1448 pg/mL, feem; P < 0.001).关于心脏生物标志物，与DCM 患者相比，MDCM 患者的NT-proBNP 水平中位数显着降低 (3 刼 p. 1 m 2 m 4 g.MDCM 患者的NT-proBNP 水平中位数显着降低（分别，与2203 pg/mL 和L0.0 pg/mL 和L0.0 Что касается сердечных биомаркеров, у пациентов с MDCM средний уровень NT-proBNP был значительно ниже по сравнению с пациентами с DCM (2203 пг/мл и 1448 пг/мл соответственно; P < 0,001). Nyob rau hauv cov nqe lus ntawm lub plawv biomarkers, txhais tau tias NT-proBNP qib tau qis dua hauv cov neeg mob MDCM piv rau cov neeg mob DCM (2203 pg / mL thiab 1448 pg / mL, feem; P < 0.001).Hauv qhov sib piv, txhais tau tias hs-CRP qib siab dua hauv cov neeg mob MDCM dua li cov neeg mob DCM (3.09 mg / L thiab 2.79 mg / L, raws li; P = 0.39).
Ntawm 282 tus neeg mob uas tau txais kev soj ntsuam echocardiographic nyob rau lub sijhawm ntawm 6 lub hlis lossis ntev dua, 7 cov neeg mob MDCM (11.1%) tau tsim DCM, thaum 70 tus neeg mob nrog DCM (32.0%) rov qab mus rau MDCM, raws li kev hloov pauv hauv LVEDDi tau pom.
Baseline MDCM cov neeg mob muaj kev pheej hmoo ntawm kev tuag tag nrho, hloov lub plawv, thiab kev nyeem ntawv rau lub plawv tsis ua hauj lwm piv rau cov neeg koom nrog DCM (adjusted hazard ratio [aHR], 0.63; 95% CI, 0.43–0.93 ; P = 0.019).
Ob theem hs-CRP thiab NT-proBNP yog tus kheej cuam tshuam nrog kev sib koom ua ke ntawm tag nrho cov kev tshawb fawb pawg (hs-CRP, aHR, 1.07; 95% CI, 1.00-1.15 thiab NT-proBNP: aHR, 1.11, 95% CI, 1.02–1.22, p = 0.019).
Tom qab sib piv cov qhab nia ntawm MDCM thiab DCM, kev sib koom ua ke ntawm cov qib siab ntawm NT-proBNP thiab cov ntsiab lus sib xyaw ua ke tau ua raws li cov lus qhia ua ntej muab piv rau cov neeg mob nrog DCM (RR, 1.83; 95% CI, 1.05–3.20; P = 0.034), tab sis tsis yog hauv cov neeg mob MDCM (HR, 1.54, 95% CI, 0.76–3.11, P = 0.227).Hauv qhov sib piv, cov qib hs-CRP tseem tseem cuam tshuam nrog kev tshwm sim hauv cov neeg mob MDCM (RR 3.19; 95% CI 1.52–6.66; P = 0.002), tab sis tsis yog hauv cov neeg mob DCM (RR 1.04; 95% CI).0.61–1.79;np = 0.88).
Ib qho kev txwv ntawm txoj kev tshawb no yog tias cov phenotype ntawm cov neeg mob tuaj yeem hloov pauv thaum rov qab los, txawm hais tias tus naj npawb ntawm cov neeg uas tau rov ua dua echocardiography tsawg heev, yog li kev kwv yees ntawm phenotypic hloov pauv tsis tau txheeb xyuas.Tsis tas li ntawd, vim yog cov qauv me me ntawm MDCM cov neeg mob hauv txoj kev tshawb no, muaj peev xwm ua rau muaj kev tsis sib haum xeeb tsis tau hloov kho tag nrho rau hauv kev tshuaj xyuas ntau yam.
"Lub hauv paus hs-CRP tau cuam tshuam nrog cov txiaj ntsig ua ke hauv MDCM cov neeg mob ua ntej thiab tom qab hloov kho covariates, thaum NT-proBNP tsuas yog cuam tshuam nrog cov txiaj ntsig hauv DCM," cov kws tshawb fawb sau tseg."Kev tshawb fawb ntxiv yog xav tau los tshawb xyuas cov kev kwv yees ntawm cov kev hloov pauv hauv ventricular geometry thiab kev ua haujlwm ntawm lub plawv, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob nrog MDCM, los muab kev pheej hmoo ntau dua."
Kev Tshaj Tawm: Tsis muaj ib tus kws sau ntawv tshawb fawb tau lees tias koom nrog biotech, kws tshuaj, thiab / lossis cov tuam txhab ntaus khoom.
Feng J, Tian P, Liang L, et al.Qhov tshwm sim thiab tus nqi prognostic ntawm N-terminal pro-brain natriuretic peptide thiab siab-rhiab heev C-reactive protein nyob rau hauv me me thiab dilated cardiomyopathies.ESC lub plawv tsis ua haujlwm.Luam tawm online Lub Peb Hlis 4, 2022 doi: 10.1002/ehf2.13864
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Koj tau saib {{metering-count}} ntawm {{metering-total}} kab lus lub hlis no.Unlimited nyeem ntawv nrog dawb nkag los yog sau npe.
Sau npe pub dawb thiab tau txais kev nkag mus tsis txwv rau: - Xov xwm kho mob - Cov ntaub ntawv tshawb fawb - Cov ntaub ntawv sib tham - Cov ntaub ntawv tag nrho - Tshuaj monographs - thiab lwm yam.